Conference Supporting Journal
Supporting Journal: Journal of Colloid and Interface Science
Article of the Month
In the run up to Colloids and Nanomedicine 2012, we are delighted to highlight a relevant article free of charge from the Journal of Colloid and Interface Science every month.
» May
» April
» March
» February
» January
» December
» November
May Article
A simple approach to covalent functionalization of boron nitride nanotubes
Journal of Colloid and Interface Science, Volume 374, Issue 1, 15 May 2012, Pages 308-314
Gianni Ciofani, Giada Graziana Genchi, Ioannis Liakos, Athanassia Athanassiou, Dinuccio Dinucci, Federica Chiellini, Virgilio Mattoli
Download PDF of this article here 
Abstract
A novel and simple method for the preparation of chemically functionalized boron nitride nanotubes (BNNTs) is presented. Thanks to a strong oxidation followed by the silanization of the surface through 3-aminopropyl-triethoxysilane (APTES), BNNTs exposing amino groups on their surface were successfully obtained. The efficacy of the procedure was assessed with EDS and XPS analyses, which demonstrated a successful functionalization of ∼15% boron sites. This approach opens interesting perspectives for further modification of BNNTs with several kinds of molecules. Since, in particular, biomedical applications are envisaged, we also demonstrated in vitro biocompatibility and cellular up-take of the functionalized BNNTs.
April Article
Resonance elastic light scattering (RELS) spectroscopy of fast non-Langmuirian ligand-exchange in glutathione-induced gold nanoparticle assembly
Journal of Colloid and Interface Science, Volume 350, Issue 1, 1 October 2010, Pages 168-177
Magdalena Stobiecka, Kaitlin Coopersmith, Maria Hepel.
Download PDF of this article here
Abstract
The interactions of a biomolecule glutathione (GSH) with citrate-capped gold nanoparticles (AuNP) have been investigated to evaluate the viability of a rapid GSH-capture by gold nanoparticle carriers, as a model system for applications ranging from designing nanoparticle-enhanced functional biosensor interfaces to nanomedicine. The measurements, performed using resonance elastic light scattering (RELS) spectroscopy, have shown a strong dependence of GSH-induced scattering cross-section on gold nanoparticle size. A large increase in RELS intensity after injection of GSH, in a short reaction time (τ = 60 s), has been observed for small AuNP (5 nm dia.) and ascribed to the fast ligand-exchange followed by AuNP assembly. The unexpected non-Langmuirian concentration dependence of scattering intensity for AuNP5nm indicates on a 2D nucleation and growth mechanism of the ligand-exchange process. The ligand-exchange and small nanoparticle ensemble formation followed by relaxation have been observed in long term (10 h) monitoring of GSH–AuNP interactions by RELS. The results of molecular dynamics and quantum mechanical calculations corroborate the mechanism of the formation of hydrogen-bonded GSH-linkages and interparticle interactions and show that the assembly is driven by multiple H-bonding between GSH-capped AuNP and electrostatic zwitterionic interactions. The RELS spectroscopy has been found as a very sensitive tool for studying interparticle interactions. The application of RELS can be expanded to monitor reactivities and assembly of other monolayer-protected metal clusters, especially in very fast processes which cannot be followed by other techniques.
March Article
Synthesis and characterization of pore size-tunable magnetic mesoporous silica nanoparticles
Journal of Colloid and Interface Science, Volume 361, Issue 1, 1 September 2011, Pages 16-24
Jixi Zhang, Xu Li, Jessica M. Rosenholm, Hong-chen Gu
Download PDF of this article here
Abstract
Magnetic mesoporous silica nanoparticles (M-MSNs) are emerging as one of the most appealing candidates for theranostic carriers. Herein, a simple synthesis method of M-MSNs with a single Fe3O4 nanocrystal core and a mesoporous shell with radially aligned pores was elaborated using tetraethyl orthosilicate (TEOS) as silica source, cationic surfactant CTAB as template, and 1,3,5-triisopropylbenzene (TMB)/decane as pore swelling agents. Due to the special localization of TMB during the synthesis process, the pore size was increased with added TMB amount within a limited range, while further employment of TMB lead to severe particle coalescence and not well-developed pore structure. On the other hand, when a proper amount of decane was jointly incorporated with limited amounts of TMB, effective pore expansion of M-MSNs similar to that of analogous mesoporous silica nanoparticles was realized. The resultant M-MSN materials possessed smaller particle size (about 40–70 nm in diameter), tunable pore sizes (3.8–6.1 nm), high surface areas (700–1100 m2/g), and large pore volumes (0.44–1.54 cm3/g). We also demonstrate their high potential in conventional DNA loading. Maximum loading capacity of salmon sperm DNA (375 mg/g) was obtained by the use of the M-MSN sample with the largest pore size of 6.1 nm.
February Article
Binding of chloroquine–conjugated gold nanoparticles with bovine serum albumin
Journal of Colloid and Interface Science, Volume 355, Issue 2, 15 March 2011, Pages 402–409
Prachi Joshi, Soumyananda Chakraborty, Sucharita Dey, Virendra Shanker, Z.A. Ansari, Surinder P. Singh, Pinak Chakrabarti
Download PDF of this article here
Abstract
We have conjugated chloroquine, an anti-malarial, antiviral and anti-tumor drug, with thiol-functionalized gold nanoparticles and studied their binding interaction with bovine serum albumin (BSA) protein. Gold nanoparticles have been synthesized using sodium borohydride as reducing agent and 11-mercaptoundecanoic acid as thiol functionalizing ligand in aqueous medium. The formation of gold nanoparticles was confirmed from the characteristic surface plasmon absorption band at 522 nm and transmission electron microscopy revealed the average particle size to be ∼7 nm. Chloroquine was conjugated to thiolated gold nanoparticles by using EDC/NHS chemistry and the binding was analyzed using optical density measurement and Fourier transform infrared spectroscopy. The chloroquine–conjugated gold nanoparticles (GNP–Chl) were found to interact efficiently with BSA. Thermodynamic parameters suggest that the binding is driven by both enthalpy and entropy, accompanied with only a minor alteration in protein’s structure. Competitive drug binding assay revealed that the GNP–Chl bind at warfarin binding site I in subdomain IIA of BSA and was further supported by Trp212 fluorescence quenching measurements. Unraveling the nature of interactions of GNP–Chl with BSA would pave the way for the design of nanotherapeutic agents with improved functionality, enriching the field of nanomedicine.
January Article
Study of the bioeffects of CdTe quantum dots on Escherichia coli cells
Journal of Colloid and Interface Science, Volume 363, Issue 2, 15 November 2011, Pages 476-480
Qisui Wang, Tingting Fang, Peng Liu, Xinmin Min, Xi Lib
Download PDF of this article here
Abstract
Quantum dots (QDs) hold great potential for applications in nanomedicine, however, only a few studies investigate their toxic- and bio-effects. Using Escherichia coli (E. coli) cells as model, we found that CdTe QDs exhibited a dose-dependent inhibitory effect on cell growth by microcalorimetric technique and optical density (OD600). The growth rate constants (k) were determined, which showed that they were related to the concentration of QDs. The mechanism of cytotoxicity of QDs was also studied through the attenuated total reflection–fourier transform infrared (ATR–FTIR) spectra, fluorescence (FL) polarization, and scanning electron microscopy (SEM). It was clear that the cell out membrane was changed or damaged by the addition of QDs. Taken together, the results indicated that CdTe QDs have cytotoxic effects on E. coli cells, and this effects might attribute to the damaged structure of the cell out membrane, thus QDs and by-products (free radicals, reactive oxygen species (ROS), and free Cd2+) which might enter the cells.
December Article
Bioreducible insulin-loaded nanoparticles and their interaction with model lipid membranes
Rickard Frost, Gregory Coué, Johan F.J. Engbersen, Michael Zäch, Bengt Kasemo, Sofia Svedhem
Journal of Colloid and Interface Science, Volume 362, Issue 2, 15 October 2011, Pages 575-583
Download PDF of this article here
Abstract
To improve design processes in the field of nanomedicine, in vitro characterization of nanoparticles with systematically varied properties is of great importance. In this study, surface sensitive analytical techniques were used to evaluate the responsiveness of nano-sized drug-loaded polyelectrolyte complexes when adsorbed to model lipid membranes. Two bioreducible poly(amidoamine)s (PAAs) containing multiple disulfide linkages in the polymer backbone (SS-PAAs) were synthesized and used to form three types of nanocomplexes by self-assembly with human insulin, used as a negatively charged model protein at neutral pH. The resulting nanoparticles collapsed on top of negatively charged model membranes upon adsorption, without disrupting the membrane integrity. These structural rearrangements may occur at a cell surface which would prevent uptake of intact nanoparticles. By the addition of glutathione, the disulfide linkages in the polymer backbone of the SS-PAAs were reduced, resulting in fragmentation of the polymer and dissociation of the adsorbed nanoparticles from the membrane. A decrease in ambient pH also resulted in destabilization of the nanoparticles and desorption from the membrane. These mimics of intracellular environments suggest dissociation of the drug formulation, a process that releases the protein drug load, when the nanocomplexes reaches the interior of a cell.
November Article
Nanoparticle carriers based on copolymers of poly(ε-caprolactone) and hyperbranched polymers for drug delivery
Tiewei Wanga, Mingjun Li, Hongxia Gao, Yan Wua,
Journal of Colloid and Interface Science, Volume 353, Issue 1, 1 January 2011, Pages 107-115
Download PDF of this article here
The Journal of Colloid and Interface Science publishes original research findings and insights regarding the fundamental principles of colloid and interface science, and conceptually novel applications of these principles in chemistry, chemical engineering, physics, applied mathematics, materials science, polymer science, electrochemistry, geology, agronomy, biology, medicine, fluid dynamics, and related fields. The Journal of Colloid and Interface Science emphasizes fundamental scientific innovation within the following categories:
- Colloidal Materials and Nanomaterials
- Surfactants and Soft Matter
- Adsorption, Catalysis and Electrochemistry
- Interfacial Processes, Capillarity and Wetting
- Biomaterials and Nanomedicine
- Novel Phenomena and Techniques
Organised by
Supporting Journal
Join us
Sponsors
